Protein Details: Short transient receptor potential channel 4-associated protein

Protein ID

ICDB_Pro_1320

Protein Name

Short transient receptor potential channel 4-associated protein

Gene Name

TRPC4AP; C20orf188; TRRP4AP

Organism

Homo sapiens (Human)

Length

797 amino acids

AlphaFoldDB

AF-Q8TEL6-F1-model_v4.pdb

Function

Sequence

MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Mitochondrial Complex Iii Deficiency;Nuclear Type 6

Location

DOI ID

10.1038/ng1285; 10.1038/414865a; 10.1101/gr.2596504; 10.1186/1471-2164-8-399; 10.1101/gad.1920310; 10.1038/nsmb.1719; 10.1073/pnas.1210303109; 10.1080/15384101.2015.1056946; 10.1016/j.cell.2018.04.028

RefSeq

NP_056453.1 [Q8TEL6-1]; NP_955400.1 [Q8TEL6-3]